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KMID : 1123920170310010046
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Korean Journal of Oriental Physiology and Pathology
2017 Volume.31 No. 1 p.46 ~ p.51
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Effects of KV Pharmacopuncture on MIA-induced Osteoarthritis Rat
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Park Byung-Jun
Choi Hak-Joo
Sim Boo-Yong
Yun Mi-Young
Yoo Ji-Hyun
Kim Dong-Hee
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Abstract
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The aim of this study is to investigate anti-arthritis activity using a KV pharmacopuncture. KV pharmacopuncture was inserted at BL40 for 4 weeks to SD-Rat, where arthritis was induced by monosodium iodoacetate (MIA) at 60 ㎎/ml. MMP-9, CTXⅡ, LTB4, calcitonin and glycosaminoglycan level in serum were measured by ELISA. The cartilage of patella volume was examined and 3-D high-resolution reconstructions of the cartilage of patella were obtained using a Micro-CT system. Also, The histopathological change of knee was observed by H&E and safranin-O staining. Production of MMP-9, CTXⅡ and LTB4 level in serum was decreased, respectively, in comparison with control. The other way, production of calcitonin and glycosaminoglycan level in serum was increased, respectively, in comparison with control. The cartilage of patella volume increased significantly. In addition, the KV group showed a increase in the cartilage volume and proteoglycan. These results may be used a remedy for new korea medicine to ease the symptoms mentioned above.
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KEYWORD
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Bone metabolism, Korea medicine, KV pharmacopunture, MIA, Osteoarthritis, Remedy
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